Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673311 | 1.00 | HTR3A (0.45) | HTR3ACHRNA7TSHRALDH1A1CYP3A4 | |
| SCHEMBL4781272 | 0.88 | CHRNA7 (0.45) | HTR3ACHRNA7TSHRHTR3EHTR3B | |
| SCHEMBL492142 | 0.83 | HTR3A (0.46) | HTR3ACHRNA7TSHRALDH1A1CYP3A4 | |
| SCHEMBL492824 | 0.83 | CHRNA7 (0.53) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL492961 | 0.83 | CHRNA7 (0.50) | HTR3ACHRNA7TSHRALDH1A1CYP3A4 | |
| SCHEMBL1567298 | 0.81 | HTR3A (0.60) | HTR3ACHRNA7TSHRALDH1A1CYP3A4 | |
| SCHEMBL491877 | 0.76 | HTR3A (0.46) | HTR3ACHRNA7CYP1A2 | |
| SCHEMBL12582692 | 0.75 | HTR3A (0.47) | HTR3ACHRNA7TSHRALDH1A1CYP3A4 | |
| SCHEMBL1966400 | 0.75 | HTR3A (0.61) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1963562 | 0.72 | CHRNA7 (0.44) | HTR3ACHRNA7TSHRHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |