Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.56 |
| ▸ | KDM6B | O15054 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917464 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1GAAGLAKDM4C | |
| Hydrochloric Acid SCHEMBL6690853 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL17163979 | 0.82 | KDM4C (0.59) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL15402395 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL2694735 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL7453387 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL17439049 | 0.81 | KDM5A (0.48) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL1232893 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1GAAGLAKDM4C | |
| SCHEMBL12516911 | 0.80 | KDM4C (0.53) | KDM4EALDH1A1GAAKDM4CKDM6B | |
| SCHEMBL17438513 | 0.80 | KDM5A (0.47) | KDM4EALDH1A1GAAGLAKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |