Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.52 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672520 | 0.95 | PTPN1 (0.50) | PTPN1NCEH1NR1H4NPC1MAPT | |
| SCHEMBL4670790 | 0.93 | PTPN1 (0.44) | PTPN1NCEH1NR1H4NPC1MAPT | |
| SCHEMBL4672473 | 0.92 | PTPN1 (0.51) | PTPN1NCEH1NR1H4SIRT3TTR | |
| SCHEMBL4673613 | 0.90 | PTPN1 (0.54) | PTPN1NR1H4SIRT3THRATHRB | |
| SCHEMBL4670378 | 0.89 | PTPN1 (0.40) | PTPN1NCEH1NPC1MAPTRAB9A | |
| SCHEMBL4676141 | 0.86 | PTPN1 (0.43) | PTPN1NCEH1NPC1MAPTRAB9A | |
| SCHEMBL4673738 | 0.86 | PTPN1 (0.52) | PTPN1NCEH1NR1H4SIRT3TTR | |
| SCHEMBL4674024 | 0.85 | PTPN1 (0.43) | PTPN1NCEH1NR1H4NPC1MAPT | |
| SCHEMBL4674098 | 0.84 | PTPN1 (0.45) | PTPN1NCEH1NR1H4NPC1MAPT | |
| SCHEMBL4675977 | 0.81 | PTPN1 (0.49) | PTPN1NCEH1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |