Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.52 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675973 | 0.93 | PTPN1 (0.44) | PTPN1NCEH1NR1H4 | |
| SCHEMBL4670309 | 0.90 | PTPN1 (0.43) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4676179 | 0.88 | NCEH1 (0.40) | PTPN1NCEH1 | |
| SCHEMBL4728486 | 0.88 | NR1H4 (0.42) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4673316 | 0.88 | PTPN1 (0.40) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4672473 | 0.88 | PTPN1 (0.51) | PTPN1NCEH1NR1H4SIRT3TTR | |
| SCHEMBL4670614 | 0.87 | PTPN1 (0.39) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4672720 | 0.87 | PTPN1 (0.39) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4674079 | 0.86 | PTPN1 (0.52) | PTPN1NCEH1NR1H4SIRT3TTR | |
| SCHEMBL4672520 | 0.86 | PTPN1 (0.50) | PTPN1NCEH1NR1H4SIRT3ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |