Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706435 | 0.93 | PDE4B (0.79) | PDE4BL3MBTL1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL3032987 | 0.91 | PDE4B (0.60) | PDE4BKDM4EBUB1RAB9ASYK | |
| SCHEMBL3022332 | 0.89 | PDE4B (0.57) | PDE4BKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1652226 | 0.88 | PDE4B (0.84) | PDE4BKDM4EABCG2L3MBTL1SMN1; SMN2 | |
| SCHEMBL4710128 | 0.88 | PDE4B (0.74) | PDE4BKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL3033443 | 0.87 | PDE4B (0.59) | PDE4BBUB1RAB9ASMN1; SMN2 | |
| SCHEMBL1653670 | 0.87 | PDE4B (0.59) | PDE4BBUB1SMN1; SMN2 | |
| SCHEMBL3033339 | 0.86 | PDE4B (0.66) | PDE4BL3MBTL1SYK | |
| SCHEMBL1652526 | 0.86 | PDE4B (0.57) | PDE4BKDM4EABCG2BUB1RAB9A | |
| SCHEMBL6167638 | 0.86 | PDE4B (0.68) | PDE4BL3MBTL1AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | claimed |