Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.68 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166894 | 0.97 | PDE4B (0.64) | PDE4BJAK1TYK2HTR1AADRA1D | |
| SCHEMBL4706435 | 0.92 | PDE4B (0.79) | PDE4BAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6170443 | 0.90 | PDE4B (0.62) | PDE4BJAK1TYK2TP53SMN1; SMN2 | |
| SCHEMBL4708773 | 0.89 | PDE4B (0.67) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4894028 | 0.87 | PDE4B (0.72) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4710128 | 0.87 | PDE4B (0.74) | PDE4BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4674510 | 0.86 | PDE4B (0.69) | PDE4BAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4706065 | 0.85 | PDE4B (0.70) | PDE4BTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4706058 | 0.85 | PDE4B (0.56) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4706107 | 0.84 | PDE4B (0.70) | PDE4BHTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |