Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035388 | 0.82 | PDE4B (0.48) | PDE4BMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4674784 | 0.82 | PDE4B (0.56) | PDE4BMAPTPOLBAHR | |
| SCHEMBL4707416 | 0.80 | PDE4B (0.80) | PDE4BMAPTSMN1; SMN2TP53ACHE | |
| SCHEMBL4708479 | 0.79 | PDE4B (0.58) | PDE4BMAPTSMN1; SMN2POLBACHE | |
| SCHEMBL4706461 | 0.78 | PDE4B (0.74) | PDE4BMAPTSMN1; SMN2TP53HTR1A | |
| SCHEMBL4707663 | 0.78 | PDE4B (0.64) | PDE4BMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4708413 | 0.77 | PDE4B (0.59) | PDE4BMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4708670 | 0.77 | PDE4B (0.63) | PDE4BMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4707585 | 0.77 | PDE4B (0.55) | PDE4BALDH1A1POLBACHEBACE1 | |
| SCHEMBL3022169 | 0.76 | PDE4B (0.47) | PDE4BTP53POLBHTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | disclosed |