Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678908 | 0.92 | PDE4B (0.67) | PDE4BMAT2ANPC1MEN1KMT2A | |
| SCHEMBL4678987 | 0.89 | SLC34A1 (0.44) | PDE4BMAPK14 | |
| SCHEMBL4675165 | 0.86 | PDE4B (0.54) | PDE4BBRAFMAT2ANPC1MEN1 | |
| SCHEMBL3039579 | 0.85 | PDE4B (0.67) | PDE4BMEN1KMT2ANOTUM | |
| SCHEMBL3022173 | 0.82 | PDE4B (0.51) | PDE4BAHRMEN1KMT2APOLB | |
| SCHEMBL4674594 | 0.82 | PDE4B (0.54) | PDE4BAHRPOLBMAPT | |
| SCHEMBL4707416 | 0.82 | PDE4B (0.80) | PDE4BMAPT | |
| SCHEMBL1651191 | 0.82 | PDE4B (0.59) | PDE4BPOLBMAPT | |
| SCHEMBL3037371 | 0.82 | PDE4B (0.54) | PDE4BAHRMEN1KMT2AMAPT | |
| SCHEMBL3029781 | 0.81 | PDE4B (0.50) | PDE4BMEN1KMT2AMAPTCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | claimed |