Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674039 | 0.84 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4675431 | 0.84 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4671515 | 0.83 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL16801495 | 0.82 | KDM4E (0.65) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6357136 | 0.81 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL8103895 | 0.81 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL9093624 | 0.78 | HTR1B (0.66) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6383923 | 0.77 | GPR119 (0.53) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL8105892 | 0.76 | SLC6A4 (0.63) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL18324775 | 0.76 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |