Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 9/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508099 | 0.86 | LMNA (0.51) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4672936 | 0.86 | LMNA (0.51) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4671483 | 0.83 | LMNA (0.47) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4730983 | 0.79 | USP5 (0.36) | MAPTL3MBTL1PROKR1SMN1; SMN2 | |
| SCHEMBL4671319 | 0.76 | LMNA (0.54) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4673603 | 0.74 | LMNA (0.51) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL7577834 | 0.73 | LMNA (0.51) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4675290 | 0.73 | LMNA (0.51) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL7464250 | 0.72 | IRAK4 (0.32) | — | |
| SCHEMBL7468984 | 0.71 | LMNA (0.40) | LMNAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | claimed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |