Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | AGBL2 | Q5U5Z8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 2/20 | 0.30 |
| ▸ | PPARA | Q07869 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22275513 | 0.77 | KDM4E (0.31) | KDM4E | |
| SCHEMBL13765709 | 0.77 | KDM4E (0.57) | KDM4EGABRR1AGBL2MAPTSMN1; SMN2 | |
| SCHEMBL4885546 | 0.74 | KDM4E (0.58) | KDM4EMAPTSMN1; SMN2HPGDNR4A2 | |
| SCHEMBL348144 | 0.74 | HCRTR1 (0.35) | HPGD | |
| SCHEMBL9411909 | 0.74 | — | — | |
| SCHEMBL10808093 | 0.73 | KDM4E (0.43) | KDM4ESMN1; SMN2GAARAB9A | |
| SCHEMBL8947745 | 0.71 | GABRP (0.34) | MAPTHPGDGAARAB9A | |
| SCHEMBL5558215 | 0.71 | KDM4E (0.51) | KDM4EGABRR1AGBL2MAPTSMN1; SMN2 | |
| SCHEMBL15637053 | 0.69 | KDM4E (0.49) | KDM4EGABRR1AGBL2MAPTSMN1; SMN2 | |
| SCHEMBL11008533 | 0.68 | KDM4E (0.76) | KDM4EMAPTHPGDHSD17B10PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |
| EP-0603419-A1 | NOVEL THIAZOLIDINEDIONE COMPOUND AND USE THEREOF | Japan Tobacco Inc. (JP) | 1994-06-29 | — | — | EP | disclosed |