Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40152 | 0.91 | SERPINE1 (0.50) | METSERPINE1MAPTCYP1A2CYP2C9 | |
| SCHEMBL39772 | 0.88 | SERPINE1 (0.47) | SERPINE1MAPTALDH1A1HTTKDM4E | |
| SCHEMBL18040373 | 0.87 | SERPINE1 (0.44) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2720586 | 0.87 | SERPINE1 (0.44) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL40086 | 0.87 | SERPINE1 (0.47) | SERPINE1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL40042 | 0.86 | SERPINE1 (0.51) | METSERPINE1MAPTCYP1A2CYP2C9 | |
| SCHEMBL19595872 | 0.84 | ALKBH5 (0.42) | METALDH1A1KDM4EPOLBALKBH5 | |
| SCHEMBL15420839 | 0.83 | CYP19A1 (0.45) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15420836 | 0.83 | CYP19A1 (0.45) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL40161 | 0.83 | SERPINE1 (0.41) | METSERPINE1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |