Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103893 | 0.82 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4676509 | 0.81 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4675431 | 0.77 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4674034 | 0.75 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4671510 | 0.74 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4674563 | 0.71 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6087738 | 0.69 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL8096606 | 0.69 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL9093624 | 0.69 | HTR1B (0.66) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6087082 | 0.69 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |