Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706461 | 0.88 | PDE4B (0.74) | PDE4BSMN1; SMN2 | |
| SCHEMBL4678908 | 0.87 | PDE4B (0.67) | PDE4BNPC1RAB9ASMN1; SMN2P2RX3 | |
| SCHEMBL3039908 | 0.86 | PDE4B (0.66) | PDE4BSMN1; SMN2HPGD | |
| SCHEMBL3038914 | 0.84 | PDE4B (0.73) | PDE4BSMN1; SMN2 | |
| SCHEMBL3039579 | 0.83 | PDE4B (0.67) | PDE4BSMN1; SMN2 | |
| SCHEMBL4707595 | 0.83 | PDE4B (0.82) | PDE4BRAB9ASMN1; SMN2 | |
| SCHEMBL4706133 | 0.83 | PDE4B (0.85) | PDE4BSMN1; SMN2 | |
| SCHEMBL4706123 | 0.82 | PDE4B (0.71) | PDE4BKDM4ESMN1; SMN2 | |
| SCHEMBL3033464 | 0.82 | PDE4B (0.60) | PDE4BRAB9AKDM4ESMN1; SMN2POLB | |
| SCHEMBL4708875 | 0.82 | PDE4B (0.70) | PDE4BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | claimed |