Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16781693 | 0.90 | ALDH1A1 (0.56) | CYP1A2ALDH1A1L3MBTL1IDO1MAPT | |
| SCHEMBL4694927 | 0.90 | ALDH1A1 (0.56) | CYP1A2ALDH1A1L3MBTL1IDO1MAPT | |
| Hydrochloric Acid SCHEMBL14119652 | 0.88 | ALDH1A1 (0.54) | CYP1A2ALDH1A1L3MBTL1IDO1MAPT | |
| Hydrochloric Acid SCHEMBL19951705 | 0.88 | ALDH1A1 (0.54) | CYP1A2ALDH1A1L3MBTL1IDO1MAPT | |
| Hydrochloric Acid SCHEMBL30098251 | 0.88 | ALDH1A1 (0.54) | CYP1A2ALDH1A1L3MBTL1IDO1MAPT | |
| SCHEMBL29242 | 0.83 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19ALDH1A1MAOB | |
| SCHEMBL28180410 | 0.83 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19ALDH1A1MAOB | |
| SCHEMBL2724772 | 0.83 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19ALDH1A1MAOB | |
| SCHEMBL11320631 | 0.83 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19ALDH1A1MAOB | |
| SCHEMBL28904973 | 0.82 | ALDH1A1 (0.58) | CYP1A2CYP2C19ALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100486969-C | Cis-2, 4, 5-triphenyl-imidazoline and application thereof in tumor treatment | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | CN | disclosed |
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1458380-B1 | CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-20040204410-A1 | CIS-imidazolines | KONG NORMAN (US) | 2004-10-14 | — | — | US | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| EP-1458380-A1 | CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-09-22 | — | — | EP | disclosed |
| US-6734302-B2 | SUCH AS 1-(4,5-BIS-(4-CHLORO-PHENYL)-2-(2,4-DIMETHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOL-1-YL)-2-METHYL-PROPAN-1-ONE WHICH INHIBITS THE INTERACTION OF MDM2 PROTEIN WITH P53-LIKE PEPTIDE; ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2004-05-11 | — | — | US | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| US-20030153580-A1 | Such as 1-(4,5-Bis-(4-chloro-phenyl)-2-(2,4-dimethoxy-phenyl)-4,5-dihydro-imidazol-1-yl)-2-methyl-propan-1-one which inhibits the interaction of MDM2 protein with p53-like peptide; antiproliferative agents | KONG NORMAN (US) | 2003-08-14 | — | — | US | disclosed |
| WO-2003051359-A1 | CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS | F.HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153580-A1 | Such as 1-(4,5-Bis-(4-chloro-phenyl)-2-(2,4-dimethoxy-phenyl)-4,5-dihydro-imidazol-1-yl)-2-methyl-propan-1-one which inhibits the interaction of MDM2 protein with p53-like peptide; antiproliferative agents | TP53, MDM2, TP53BP1 | CYP1A2 4300/4885CYP2C9 4417/4885CYP2C19 4168/4885 |
| US-20040204410-A1 | CIS-imidazolines | TP53, MDM2, TP53BP1 | CYP1A2 3316/4885CYP2C9 2456/4885CYP2C19 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.