Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467688 | 0.95 | AXL (0.40) | AXLADORA2AADORA1KDRINSR | |
| SCHEMBL467659 | 0.93 | AXL (0.49) | AXLL3MBTL3L3MBTL1FGFR1FLT1 | |
| SCHEMBL467833 | 0.90 | AXL (0.47) | AXLL3MBTL3L3MBTL1FGFR1FLT1 | |
| SCHEMBL467696 | 0.84 | AXL (0.43) | AXLL3MBTL1FGFR1KDRINSR | |
| SCHEMBL467478 | 0.84 | AXL (0.42) | AXLKDRINSR | |
| SCHEMBL27769653 | 0.84 | AXL (0.42) | AXLL3MBTL3L3MBTL1KDRINSR | |
| SCHEMBL27790975 | 0.83 | AXL (0.47) | AXLKDRINSRHRH3 | |
| SCHEMBL30090809 | 0.83 | AXL (0.47) | AXLKDRINSRHRH3 | |
| SCHEMBL28997487 | 0.82 | AXL (0.35) | AXLADORA2AADORA1 | |
| SCHEMBL28997485 | 0.82 | AXL (0.35) | AXLADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |