Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.33 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | S100B | P04271 | 1/20 | 0.33 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467659 | 0.97 | AXL (0.49) | AXLL3MBTL3L3MBTL1KDRINSR | |
| SCHEMBL467688 | 0.92 | AXL (0.40) | AXLKDRINSRCSF1RCDK4 | |
| SCHEMBL467792 | 0.90 | AXL (0.44) | AXLL3MBTL3L3MBTL1KDRINSR | |
| SCHEMBL27790975 | 0.89 | AXL (0.47) | AXLKDRINSRALDH1A1HRH3 | |
| SCHEMBL30090809 | 0.89 | AXL (0.47) | AXLKDRINSRALDH1A1HRH3 | |
| SCHEMBL27769653 | 0.87 | AXL (0.42) | AXLL3MBTL3L3MBTL1KDRINSR | |
| SCHEMBL467696 | 0.87 | AXL (0.43) | AXLL3MBTL1KDRINSRFGFR1 | |
| SCHEMBL467478 | 0.87 | AXL (0.42) | AXLKDRINSRALDH1A1SMN1; SMN2 | |
| SCHEMBL467749 | 0.85 | AXL (0.40) | AXLKDRINSRCSF1RCDK4 | |
| SCHEMBL468621 | 0.84 | L3MBTL3 (0.43) | AXLL3MBTL3L3MBTL1MBTD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |