Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 7/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | FAAH | O00519 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677289 | 0.90 | CCR3 (0.52) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4673649 | 0.90 | CCR3 (0.57) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4674212 | 0.89 | CCR3 (0.51) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4673476 | 0.87 | CCR3 (0.51) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4674096 | 0.87 | CCR3 (0.57) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4674893 | 0.87 | ACHE (0.53) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| Hydrochloric Acid SCHEMBL4680263 | 0.86 | CCR3 (0.56) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4676719 | 0.86 | CCR3 (0.56) | CCR3ACHEBCHEFAAHSIGMAR1 | |
| SCHEMBL4673840 | 0.86 | CCR3 (0.56) | CCR3ACHEBCHEFAAHCACNA1G | |
| SCHEMBL4673007 | 0.85 | CCR3 (0.54) | CCR3ACHEBCHEFAAHSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | claimed |
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | disclosed |