Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BRS3 | P32247 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671760 | 0.84 | MEN1 (0.35) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4672873 | 0.82 | ALDH1A1 (0.41) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4678961 | 0.81 | PTGER1 (0.36) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4678600 | 0.81 | HSD17B10 (0.41) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4672893 | 0.81 | SMN1; SMN2 (0.34) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4675232 | 0.80 | ALDH1A1 (0.44) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4675956 | 0.80 | KMT2A (0.38) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4671985 | 0.80 | TDP1 (0.32) | NPC1RAB9APOLBKMT2ASMN1; SMN2 | |
| S-1360 SCHEMBL10070153 | 0.80 | CYP1A2 (0.36) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL4676637 | 0.80 | ELANE (0.33) | SMN1; SMN2TDP1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142872-B1 | AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES | SHIONOGI & CO (JP) | 2008-10-15 | — | — | EP | disclosed |
| CN-1335834-A | Aromatic heterocyclic compounds having HIV integrase inhibitory activity | SHIONOGI & CO (JP) | 2002-02-13 | — | — | CN | disclosed |