Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.55 |
| ▸ | CTSK | P43235 | 13/20 | 0.55 |
| ▸ | CTSS | P25774 | 12/20 | 0.55 |
| ▸ | CTSB | P07858 | 11/20 | 0.55 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2156958 | 1.00 | CTSL (0.55) | CTSLCTSKCTSSCTSBFPR2 | |
| SCHEMBL2155289 | 1.00 | CTSL (0.55) | CTSLCTSKCTSSCTSBFPR2 | |
| SCHEMBL2156241 | 0.84 | CTSL (0.76) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8354274 | 0.84 | CTSL (0.76) | CTSLCTSKCTSSCTSB | |
| SCHEMBL4672639 | 0.84 | CTSL (0.57) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL2131045 | 0.83 | CTSL (0.61) | CTSLCTSKCTSSCTSBFPR2 | |
| SCHEMBL4419936 | 0.83 | CTSL (0.61) | CTSLCTSKCTSSCTSBFPR2 | |
| SCHEMBL3767672 | 0.83 | CTSL (0.55) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL4085485 | 0.83 | CTSL (0.72) | CTSLCTSKCTSSCTSBFPR2 | |
| SCHEMBL1169219 | 0.83 | CTSL (0.72) | CTSLCTSKCTSSCTSBFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100430052-C | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA INC (CA) | 2008-11-05 | — | — | CN | disclosed |
| EP-1482924-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-05-21 | — | — | EP | disclosed |
| EP-1482924-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2006-03-08 | — | — | EP | disclosed |
| CN-1638757-A | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA INC (CA) | 2005-07-13 | — | — | CN | disclosed |
| EP-1482924-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075836-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-09-18 | — | — | WO | disclosed |