Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.79 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326633 | 0.88 | HTR6 (1.00) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL14143216 | 0.86 | HTR6 (0.79) | HTR6ADRB1HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL7008069 | 0.84 | HTR6 (0.91) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL5202731 | 0.82 | HTR6 (0.62) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4676917 | 0.80 | HTR6 (0.71) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL4676720 | 0.77 | HTR6 (0.71) | HTR6ADRB1HTR1AHTR2AHTR7 | |
| SCHEMBL4675570 | 0.77 | HTR6 (0.71) | HTR6ADRB1HTR1AHTR2AHTR7 | |
| SCHEMBL4675814 | 0.76 | HTR6 (0.70) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL4676415 | 0.76 | HTR6 (0.49) | HTR6 | |
| SCHEMBL4675283 | 0.75 | HTR6 (0.76) | HTR6HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542973-B1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | claimed |
| EP-1542973-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | claimed |
| WO-2004026831-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | claimed |
| EP-1542973-B1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| US-7381739-B2 | Antiserotonine agents; central nervous system disorders; Alzheimer's disease; Parkinson's disease; Huntington's disease; sleep disorders | ROCHE PALO ALTO LLC (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381739-B2 | Antiserotonine agents; central nervous system disorders; Alzheimer's disease; Parkinson's disease; Huntington's disease; sleep disorders | ROCHE PALO ALTO LLC (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381739-B2 | Antiserotonine agents; central nervous system disorders; Alzheimer's disease; Parkinson's disease; Huntington's disease; sleep disorders | ROCHE PALO ALTO LLC (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1542973-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026831-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |