Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.63 |
| ▸ | HRH1 | P35367 | 4/20 | 0.59 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | CNR1 | P21554 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6420673 | 0.86 | NOTUM (0.61) | SLC6A4HRH1SMPD1LMNAMAPT | |
| SCHEMBL4733904 | 0.85 | SLC6A4 (0.65) | SLC6A4HRH1SMPD1LMNAMAPT | |
| SCHEMBL7813757 | 0.82 | SLC6A4 (0.54) | SLC6A4HRH1CHRM1DRD2ADRA2B | |
| Hydrochloric Acid SCHEMBL7813755 | 0.81 | CYP3A4 (0.55) | SLC6A4HRH1LMNAMAPTCHRM1 | |
| SCHEMBL7808599 | 0.80 | SLC6A4 (0.54) | SLC6A4HRH1SMPD1LMNAMAPT | |
| Bromide SCHEMBL284961 | 0.79 | NAMPT (0.53) | SLC6A4CNR1ALDH1A1HTR7KMT2A | |
| SCHEMBL218473 | 0.77 | SLC6A4 (0.66) | SLC6A4HRH1SMPD1LMNAMAPT | |
| SCHEMBL6966501 | 0.77 | DRD3 (0.58) | SLC6A4CHRM1DRD2CHRM3SLC6A2 | |
| SCHEMBL8172344 | 0.77 | CHRM1 (0.62) | CHRM1DRD2CHRM3ADRA1ADRD3 | |
| Imipramine SCHEMBL20644144 | 0.77 | SLC6A4 (0.83) | SLC6A4HRH1SMPD1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216994-B1 | Tricyclic antidepressant derivatives and immunoassay | ROCHE DIAGNOSTICS GMBH (DE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1216994-B1 | Tricyclic antidepressant derivatives and immunoassay | ROCHE DIAGNOSTICS GMBH (DE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1216994-A2 | Tricyclic antidepressant derivatives and immunoassay | Roche Diagnostics GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6368814-B1 | TRICYCLIC ANTIDEPRESSANTS AND METABOLITES THEREOF | ROCHE DIAGNOSTICS CORPORATION | 2002-04-09 | — | — | US | disclosed |