Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684044 | 1.00 | GRM2 (0.34) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL4678930 | 1.00 | GRM2 (0.34) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL4682912 | 0.80 | GRM2 (0.36) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL4683778 | 0.80 | GRM2 (0.36) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL4682908 | 0.80 | GRM2 (0.36) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL25763004 | 0.68 | HPGD (0.34) | ALDH1A1LMNAHTT | |
| SCHEMBL29062970 | 0.68 | HPGD (0.34) | ALDH1A1LMNAHTT | |
| SCHEMBL15803826 | 0.66 | RECQL (0.50) | GRM2ALDH1A1HTT | |
| SCHEMBL29063201 | 0.65 | ALDH1A1 (0.38) | ALDH1A1TDP1LMNAHTT | |
| SCHEMBL25762998 | 0.65 | ALDH1A1 (0.38) | ALDH1A1TDP1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-B1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-03-05 | — | — | EP | disclosed |
| US-6284768-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| US-6268365-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-07-31 | — | — | US | disclosed |
| US-6054470-A | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-04-25 | — | — | US | disclosed |