Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676348 | 0.89 | PDE4B (0.67) | PDE4BTBXAS1TP53 | |
| SCHEMBL3022117 | 0.88 | PDE4B (0.62) | PDE4BTBXAS1TP53LMNA | |
| SCHEMBL3028542 | 0.87 | PDE4B (0.54) | PDE4BTP53 | |
| SCHEMBL3029482 | 0.86 | PDE4B (0.52) | PDE4BTBXAS1THRB | |
| SCHEMBL4678287 | 0.85 | PDE4B (0.52) | PDE4BKDM4CTP53 | |
| SCHEMBL3033040 | 0.84 | PDE4B (0.55) | PDE4BTBXAS1TP53 | |
| SCHEMBL3038012 | 0.84 | PDE4B (0.55) | PDE4BTBXAS1 | |
| SCHEMBL4053752 | 0.84 | PDE4B (0.49) | PDE4BTBXAS1TP53LMNA | |
| SCHEMBL4050522 | 0.83 | PDE4B (0.55) | PDE4BTBXAS1TP53 | |
| SCHEMBL3039960 | 0.83 | PDE4B (0.52) | PDE4BTBXAS1TP53LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | claimed |