Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.91 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680034 | 0.96 | CYP2D6 (1.00) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| SCHEMBL4679167 | 0.96 | CYP2D6 (1.00) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| SCHEMBL4679045 | 0.96 | CYP2D6 (1.00) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| Hydrochloric Acid SCHEMBL4678173 | 0.95 | CYP2D6 (0.98) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| Hydrochloric Acid SCHEMBL4678178 | 0.95 | CYP2D6 (0.98) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| SCHEMBL27501473 | 0.90 | CYP2D6 (0.90) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| SCHEMBL4679094 | 0.90 | CYP2D6 (0.86) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| SCHEMBL4679097 | 0.90 | CYP2D6 (0.86) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| Hydrochloric Acid SCHEMBL4685873 | 0.90 | CYP2D6 (0.88) | CYP2D6CHRM5CHRM1MAPK14CXCR3 | |
| Hydrochloric Acid SCHEMBL4680063 | 0.89 | CYP2D6 (0.88) | CYP2D6CHRM5CHRM1MAPK14CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |