Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.80 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.80 |
| ▸ | STK10 | O94804 | 1/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.80 |
| ▸ | INSR | P06213 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.80 |
| ▸ | SRC | P12931 | 1/20 | 0.80 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.80 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.80 |
| ▸ | CDK2 | P24941 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006411 | 0.90 | EGFR (1.00) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL29351024 | 0.89 | EGFR (1.00) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL8100 | 0.89 | EGFR (1.00) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL16766960 | 0.89 | EGFR (1.00) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL29464189 | 0.89 | EGFR (1.00) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL3232064 | 0.88 | EGFR (0.99) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| SCHEMBL13594227 | 0.88 | EGFR (0.89) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL4924110 | 0.88 | EGFR (0.99) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL3637153 | 0.88 | EGFR (0.99) | EGFRERBB2MEN1PIK3C2BMAP2K7 | |
| Lapatinib SCHEMBL574229 | 0.88 | EGFR (0.99) | EGFRERBB2MEN1PIK3C2BMAP2K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403339-A1 | COMBINATION CANCER THERAPY WITH AN AKT INHIBITOR AND OTHER ANTICANCER AGENTS | Merck Sharp & Dohme Corp. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101734-A1 | COMBINATION CANCER THERAPY WITH AN AKT INHIBITOR AND OTHER ANTICANCER AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-10 | — | — | WO | disclosed |