Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578263 | 1.00 | P2RX7 (0.58) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL9578261 | 1.00 | P2RX7 (0.58) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL9578249 | 1.00 | P2RX7 (0.58) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL9578256 | 1.00 | P2RX7 (0.58) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL4696045 | 0.93 | MDM2 (0.61) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL15099554 | 0.93 | P2RX7 (0.51) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL14160015 | 0.93 | MDM2 (0.61) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL15096110 | 0.88 | P2RX7 (0.47) | P2RX7TGFBR1MDM2ALDH1A1MAPT | |
| SCHEMBL4680050 | 0.82 | MDM2 (0.51) | P2RX7TGFBR1MDM2MAPTKDM4E | |
| SCHEMBL4677500 | 0.82 | MDM2 (0.51) | P2RX7TGFBR1MDM2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433682-A2 | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer | MARION MERRELL DOW INC. (US) | 1991-06-26 | — | — | EP | claimed |
| JP-3170424-A | — | — | None | — | — | JP | disclosed |
| EP-1458380-B1 | CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-5182268-A | Pharmaceutical composition comprising daunorubicin potentiated with 2,4,5-tri (4-methoxyphenyl)-4,5-dihydroimidazole | MARION MERRELL DOW, INC. (US) | 1993-01-26 | — | — | US | disclosed |
| US-5182268-A | Pharmaceutical composition comprising daunorubicin potentiated with 2,4,5-tri (4-methoxyphenyl)-4,5-dihydroimidazole | MARION MERRELL DOW, INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0433682-A3 | USE OF 2,4,5-TRI(4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOLE FOR THE TREATMENT OF CANCER | — | 1992-02-26 | — | — | EP | disclosed |
| JP-H03170424-A | TREATMENT OF CANCER | MARION MERRELL DOW INC | 1991-07-24 | — | — | JP | disclosed |
| EP-0433682-A2 | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer | MARION MERRELL DOW INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0433682-A2 | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer | MARION MERRELL DOW INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0433682-A2 | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer | MARION MERRELL DOW INC. (US) | 1991-06-26 | — | — | EP | disclosed |