Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.71 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461964 | 0.88 | PARP1 (0.58) | PARP1PARP2 | |
| SCHEMBL423551 | 0.84 | PARP1 (1.00) | PARP1DHODHAURKBPLA2G2AALOX15 | |
| SCHEMBL29380664 | 0.84 | PARP1 (1.00) | PARP1DHODHAURKBPLA2G2AALOX15 | |
| SCHEMBL5630156 | 0.80 | PARP1 (0.61) | PARP1AURKBAURKAPARP2 | |
| SCHEMBL12385320 | 0.80 | PARP1 (0.62) | PARP1DHODHAURKBPARP2PLK4 | |
| SCHEMBL28263632 | 0.78 | KDM4E (0.50) | PARP1DHODH | |
| SCHEMBL29180021 | 0.76 | PARP1 (0.73) | PARP1DHODHAURKBAURKAPLA2G2A | |
| SCHEMBL18252746 | 0.76 | PARP1 (0.78) | PARP1DHODHAURKBPLA2G2AALOX15 | |
| SCHEMBL29180033 | 0.75 | PARP1 (0.68) | PARP1DHODHAURKBAURKAPLA2G2A | |
| SCHEMBL30811237 | 0.75 | PARP1 (0.68) | PARP1DHODHAURKBAURKAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387403-A1 | METHOD OF TREATING CANCER | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253692-A1 | Electrical heater for vehicle windshields and windows | SCHAUBLE RICHARD EGON | 2011-10-20 | — | — | US | disclosed |