Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 11/20 | 0.37 |
| ▸ | MC3R | P41968 | 5/20 | 0.37 |
| ▸ | MC5R | P33032 | 4/20 | 0.35 |
| ▸ | MC1R | Q01726 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.33 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.33 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.33 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.33 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.33 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.33 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698319 | 0.94 | MC4R (0.41) | MC4RMC3RMC5RMC1RCYP3A4 | |
| SCHEMBL4698284 | 0.81 | MC4R (0.40) | MC4RMC3RMC5RMC1RALDH1A1 | |
| SCHEMBL4699797 | 0.73 | TACR1 (0.46) | MC4RMC3RMC5RMC1ROPRM1 | |
| SCHEMBL4514425 | 0.66 | MC4R (0.43) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4530098 | 0.66 | MC4R (0.43) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4703101 | 0.63 | KMT2A (0.49) | MC4RMC3RMC5RMC1RCCR1 | |
| SCHEMBL4700274 | 0.62 | MC4R (0.41) | MC4RMC3RMC5RMC1RCCR1 | |
| SCHEMBL3235874 | 0.62 | MC4R (0.65) | MC4RMC3RMC5RMC1R | |
| SCHEMBL3235881 | 0.62 | MC4R (0.65) | MC4RMC3RMC5RMC1R | |
| SCHEMBL3239970 | 0.62 | MC4R (0.65) | MC4RMC3RMC5RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B8 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1416933-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgem, Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009847-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM, INC. (US) | 2003-02-06 | — | — | WO | disclosed |