Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 19/20 | 0.40 |
| ▸ | MC3R | P41968 | 5/20 | 0.40 |
| ▸ | MC5R | P33032 | 4/20 | 0.38 |
| ▸ | MC1R | Q01726 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698319 | 0.87 | MC4R (0.41) | MC4RMC3RMC5RMC1RCYP3A4 | |
| SCHEMBL4680189 | 0.81 | MC4R (0.37) | MC4RMC3RMC5RMC1RCYP3A4 | |
| SCHEMBL4699797 | 0.77 | TACR1 (0.46) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4514425 | 0.71 | MC4R (0.43) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4530098 | 0.71 | MC4R (0.43) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4679870 | 0.70 | CYP51A1 (0.44) | MC4RMC3RMC5RMC1RCYP3A4 | |
| SCHEMBL4679868 | 0.69 | MC4R (0.48) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4702664 | 0.68 | MC4R (0.45) | MC4R | |
| SCHEMBL4700300 | 0.67 | KMT2A (0.49) | MC4RMC3RMC5RMC1R | |
| SCHEMBL4697707 | 0.66 | MC4R (0.40) | MC4RMC3RMC5RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | claimed |
| US-20040006067-A1 | Substituted piperidines and methods of use | AMGEN INC. | 2004-01-08 | — | — | US | claimed |
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | disclosed |
| US-6977264-B2 | Substituted piperidines and methods of use | AMGEN INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-20040006067-A1 | Substituted piperidines and methods of use | AMGEN INC. | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006067-A1 | Substituted piperidines and methods of use | MC4R, MC5R, MC1R | MC4R 1/4885MC3R 4/4885MC5R 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.