Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682588 | 0.88 | CNR1 (0.65) | CNR1CNR2 | |
| SCHEMBL4679000 | 0.83 | CNR1 (0.56) | CNR1SMN1; SMN2CNR2LIPEKDM4E | |
| SCHEMBL4681648 | 0.83 | CNR1 (0.48) | CNR1CNR2 | |
| SCHEMBL4680422 | 0.82 | CNR1 (0.59) | CNR1CNR2CYP2C9GPR55 | |
| SCHEMBL4676951 | 0.82 | CNR1 (0.59) | CNR1CNR2CYP2C9GPR55 | |
| Thiotepa SCHEMBL5237308 | 0.80 | CNR1 (0.55) | CNR1CNR2 | |
| SCHEMBL4676993 | 0.78 | CNR1 (0.53) | CNR1SMN1; SMN2CNR2KDM4E | |
| SCHEMBL4681752 | 0.78 | CNR1 (0.52) | CNR1SMN1; SMN2CNR2LIPEKDM4E | |
| SCHEMBL4676256 | 0.77 | CDH1 (0.57) | CNR1SMN1; SMN2POLBKDM4ECYP1A2 | |
| SCHEMBL6823078 | 0.76 | CNR1 (0.62) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |