Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 4/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722198 | 0.83 | PDPK1 (0.77) | PDPK1LOXL2ADRB2CYP2A6HDAC3 | |
| SCHEMBL679895 | 0.81 | PDPK1 (0.57) | PDPK1LOXL2KIF11ADRB2CYP2A6 | |
| SCHEMBL3069106 | 0.79 | PDPK1 (0.55) | PDPK1LOXL2CYP2A6KDM4EMEN1 | |
| SCHEMBL4589649 | 0.78 | PDPK1 (0.63) | PDPK1LOXL2SYKFBP1ADRB2 | |
| SCHEMBL19219079 | 0.78 | PDPK1 (0.63) | PDPK1LOXL2ADRB2CYP2A6KDM4E | |
| SCHEMBL15668775 | 0.77 | SYK (0.50) | SYKFBP1KDM4EMEN1KMT2A | |
| SCHEMBL1653986 | 0.77 | PDPK1 (0.68) | PDPK1LOXL2ADRB2CYP2A6KDM4E | |
| SCHEMBL468075 | 0.77 | PDPK1 (0.52) | PDPK1LOXL2ADRB2CYP2A6KDM4E | |
| SCHEMBL17801290 | 0.77 | CYP2A6 (0.50) | PDPK1LOXL2SYKADRB2CYP2A6 | |
| SCHEMBL20422053 | 0.77 | SYK (0.52) | PDPK1SYKFBP1KIF11CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110603254-B | Substituted pyrazole compounds and methods of using the same for treating hyperproliferative diseases | 班塔姆制药有限责任公司 | 2024-04-12 | — | — | CN | claimed |
| CN-110603254-A | Substituted pyrazole compounds and methods of using the same for treating hyperproliferative diseases | 班塔姆制药有限责任公司 | 2019-12-20 | — | — | CN | claimed |
| CN-110103529-A | A kind of sphygmomanometer environment-friendly composite material and preparation method thereof | 王才阳 | 2019-08-09 | — | — | CN | claimed |
| CN-108383858-B | Derivatives of imidazothiadiazoles and imidazopyrazines for the treatment of platelet aggregation | 百时美施贵宝公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-110603254-B | Substituted pyrazole compounds and methods of using the same for treating hyperproliferative diseases | 班塔姆制药有限责任公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-110049973-B | 1, 4-diphenyl-1H-imidazole and 2, 4-diphenyl thiazole derivatives, and preparation method and application thereof | 南方医科大学 | 2023-02-17 | — | — | CN | disclosed |
| EP-4101297-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Pharmaceuticals, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| US-20220211675-A1 | TIE-2 ACTIVATORS TARGETING THE SCHLEMM'S CANAL | EyePoint, Inc. | 2022-07-07 | — | — | US | disclosed |
| US-20220117946-A1 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE | EyePoint Pharmaceuticals, Inc. | 2022-04-21 | — | — | US | disclosed |
| CN-114269341-A | Tie-2 activator targeting Schlemm's canal | 视点制药公司 | 2022-04-01 | — | — | CN | disclosed |
| US-11253502-B2 | Tie-2 activators targeting the Schlemm's canal | EyePoint Pharmaceuticals, Inc. (US) | 2022-02-22 | — | — | US | disclosed |
| WO-2003072102-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| WO-2003072100-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| EP-0538310-B1 | ETHYNYLBENZOTHIOPHENE PESTICIDES | FMC CORP (US) | 1995-09-13 | — | — | EP | disclosed |
| EP-0538310-A4 | ETHYNYLBENZOTHIOPHENE PESTICIDES | — | 1993-07-14 | — | — | EP | disclosed |
| EP-0538310-A1 | ETHYNYLBENZOTHIOPHENE PESTICIDES. | FMC CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000672-A1 | ETHYNYLBENZOTHIOPHENE PESTICIDES | FMC CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |
| US-5073564-A | Photoactivated insecticides | FMC CORPORATION (US) | 1991-12-17 | — | — | US | disclosed |
| US-4889867-A | Photoactivated miticidal and insecticidal ethynyl-thiazoles | FMC CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4788207-A | Photoactivated miticidal and insecticidal ethynylthiazoles | FMC CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220117946-A1 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE | PTPRCAP, PTPRC, PPP5C | PDPK1 635/4885LOXL2 1265/4885SYK 735/4885 |
| US-20220211675-A1 | TIE-2 ACTIVATORS TARGETING THE SCHLEMM'S CANAL | TIE1, TEK, TGFB2 | PDPK1 1101/4885LOXL2 169/4885SYK 1922/4885 |
| US-11253502-B2 | Tie-2 activators targeting the Schlemm's canal | TIE1, TEK, TGFB2 | PDPK1 1101/4885LOXL2 169/4885SYK 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.