Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.63 |
| ▸ | PPARA | Q07869 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680583 | 1.00 | PPARG (0.63) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL14501493 | 0.89 | PPARG (0.61) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL14501559 | 0.89 | PPARG (0.51) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL2719676 | 0.89 | PPARG (0.59) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL2719672 | 0.89 | PPARG (0.59) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL2720809 | 0.89 | PPARG (0.64) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL2720808 | 0.89 | PPARG (0.64) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL4683386 | 0.88 | PPARG (0.80) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL14501384 | 0.88 | PPARG (0.57) | PPARGPPARAALDH1A1MEN1LMNA | |
| SCHEMBL6600187 | 0.88 | PPARG (0.80) | PPARGPPARAALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1386913-B1 | PYRROLE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-7220773-B2 | Heterocylic amines used as antidiabetic or hyperglycemic agents | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| US-7220773-B2 | Heterocylic amines used as antidiabetic or hyperglycemic agents | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| US-7220773-B2 | Heterocylic amines used as antidiabetic or hyperglycemic agents | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |