Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | GSR | P00390 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683600 | 0.98 | GRM5 (0.40) | GRM5GRM1ALOX12MDM2CYP11B2 | |
| SCHEMBL4683064 | 0.97 | GRM1 (0.39) | GRM5GRM1ALOX12MDM2CYP11B2 | |
| SCHEMBL4679352 | 0.91 | GRM5 (0.46) | GRM5CYP2C19ALDH1A1 | |
| SCHEMBL6103711 | 0.85 | GRM5 (0.41) | GRM5MDM2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4682564 | 0.80 | GRM5 (0.37) | GRM5MDM2AKT1CYP1A2CYP3A4 | |
| SCHEMBL6103251 | 0.80 | GRM5 (0.46) | GRM5MEN1KMT2AAKT1CYP1A2 | |
| SCHEMBL15071808 | 0.79 | CYP11B2 (0.36) | GRM1CYP11B2AKT1CYP11B1MAPT | |
| SCHEMBL13706965 | 0.79 | GRM5 (0.49) | GRM5GRM1CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL4678329 | 0.76 | USP8 (0.44) | GRM5GRM1CYP11B2MEN1KMT2A | |
| SCHEMBL4686026 | 0.75 | USP8 (0.42) | GRM5GRM1CYP11B2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |