Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 19/20 | 0.50 |
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676879 | 1.00 | CNR1 (0.50) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4677622 | 0.86 | CNR1 (0.52) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4677619 | 0.86 | CNR1 (0.52) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4677625 | 0.86 | CNR1 (0.52) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4677897 | 0.86 | CNR1 (0.52) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4677901 | 0.86 | CNR1 (0.52) | CNR1CNR2TACR2TRPV1 | |
| SCHEMBL4676935 | 0.80 | CNR1 (0.62) | CNR1CNR2 | |
| SCHEMBL4681579 | 0.78 | CNR1 (0.55) | CNR1CNR2TRPV1 | |
| SCHEMBL4681584 | 0.78 | CNR1 (0.55) | CNR1CNR2TRPV1 | |
| SCHEMBL4677448 | 0.78 | CNR1 (0.55) | CNR1CNR2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |