Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681163 | 0.87 | CNR1 (0.67) | CNR1PDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL4684187 | 0.83 | CNR1 (0.42) | CNR1CNR2 | |
| SCHEMBL4676879 | 0.80 | CNR1 (0.50) | CNR1CNR2 | |
| SCHEMBL4680943 | 0.80 | CNR1 (0.50) | CNR1CNR2 | |
| SCHEMBL4684112 | 0.80 | CNR1 (0.70) | CNR1PDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL4679409 | 0.77 | CNR1 (1.00) | CNR1PDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL28759848 | 0.76 | CNR1 (0.53) | CNR1PDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL4681583 | 0.75 | CNR1 (0.53) | CNR1NR1H4CNR2 | |
| SCHEMBL4681802 | 0.75 | CNR1 (0.49) | CNR1PDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL4679252 | 0.75 | HTT (0.44) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |