Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037390 | 0.87 | MAPT (0.40) | MAPTALDH1A1GAAROCK1MAPK1 | |
| SCHEMBL994138 | 0.87 | MAPT (0.49) | MAPTALDH1A1GAAROCK1SMN1; SMN2 | |
| SCHEMBL1377025 | 0.84 | MAPK1 (0.46) | MAPTALDH1A1GAAROCK1MAPK1 | |
| SCHEMBL3033408 | 0.84 | PTGS2 (0.42) | MAPTALDH1A1GAAROCK1 | |
| SCHEMBL3036670 | 0.84 | MAP2K4 (0.45) | ALDH1A1 | |
| SCHEMBL1376313 | 0.82 | GSK3A (0.50) | MAPTALDH1A1PDE1APDE1BPDE3B | |
| SCHEMBL4708510 | 0.82 | ROCK1 (0.36) | MAPTALDH1A1GAAROCK1 | |
| SCHEMBL3027304 | 0.82 | KIT (0.38) | MAPTALDH1A1GAA | |
| SCHEMBL3028596 | 0.80 | NOTUM (0.45) | MAPTALDH1A1GAAROCK1SMN1; SMN2 | |
| SCHEMBL3022888 | 0.78 | MAPK1 (0.57) | MAPTALDH1A1ROCK1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | disclosed |