Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | USP21 | Q9UK80 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20475056 | 0.86 | PTPRB (0.44) | PTPRBCCR3NPC1TP53RAB9A | |
| SCHEMBL679776 | 0.84 | PTPRB (0.51) | PTPRBCCR3NPC1TP53RAB9A | |
| SCHEMBL24534145 | 0.76 | RAB9A (0.41) | PTPRBCCR3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL933361 | 0.76 | PTPRB (0.42) | PTPRBCCR3NPC1TP53RAB9A | |
| SCHEMBL16059878 | 0.76 | PTPRB (0.42) | PTPRBCCR3NPC1TP53RAB9A | |
| SCHEMBL679129 | 0.75 | PTPRB (0.49) | PTPRBCCR3NPC1TP53RAB9A | |
| SCHEMBL679881 | 0.75 | PTPRB (0.61) | PTPRBCCR3MEN1KMT2A | |
| SCHEMBL679882 | 0.75 | PTPRB (0.61) | PTPRBCCR3MEN1KMT2A | |
| SCHEMBL17974590 | 0.74 | PTPRB (0.60) | PTPRBCCR3MEN1KMT2A | |
| SCHEMBL684241 | 0.73 | PTPRB (0.72) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385763-A1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | Akebia Therapeutics Inc. (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110253725-A1 | MULTI-PORT BEVERAGE AND FOOD CONTAINERS | KILLIAN WILLIAM | 2011-10-20 | — | — | US | disclosed |
| WO-2011005330-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | AKEBIA THERAPEUTICS INC. (US) | 2011-01-13 | — | — | WO | disclosed |