Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685575 | 0.92 | MCHR1 (0.37) | KCNH2CYP2D6TACR1OPRK1 | |
| SCHEMBL4678953 | 0.91 | USP2 (0.42) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| Water SCHEMBL4680295 | 0.91 | CNR1 (0.40) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| SCHEMBL4679834 | 0.89 | KMT2A (0.47) | HTR2AHTR2CHTR2BCYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL4680927 | 0.88 | KMT2A (0.46) | HTR2AHTR2CHTR2BCYP2D6KMT2A | |
| SCHEMBL4682814 | 0.88 | KMT2A (0.40) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| SCHEMBL4682468 | 0.87 | USP2 (0.41) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| Water SCHEMBL4682572 | 0.87 | CYP2D6 (0.48) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| SCHEMBL4679944 | 0.86 | CYP2D6 (0.42) | USP2CYP3A4HRH1KCNH2NR1I2 | |
| Water SCHEMBL7873458 | 0.82 | LMNA (0.39) | CYP3A4KCNH2HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |