Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4683890 | 0.99 | CYP2D6 (0.47) | CYP2D6MEN1KMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL4683561 | 0.99 | CYP2D6 (0.47) | CYP2D6MEN1KMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL4679838 | 0.93 | CYP2D6 (0.54) | CYP2D6MEN1KMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL4678397 | 0.91 | MEN1 (0.50) | CYP2D6MEN1KMT2APOLBMAPT | |
| SCHEMBL4678497 | 0.88 | CYP2D6 (0.51) | CYP2D6MEN1KMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL4682834 | 0.87 | CYP2D6 (0.48) | CYP2D6MEN1KMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL4682628 | 0.87 | CYP2D6 (0.48) | CYP2D6MEN1KMT2APOLBMAPT | |
| SCHEMBL4682634 | 0.86 | ACKR3 (0.47) | CYP2D6MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4682633 | 0.86 | ACKR3 (0.47) | CYP2D6MEN1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4681798 | 0.86 | ACKR3 (0.47) | CYP2D6MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |