Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021145 | 0.83 | ALDH1A1 (0.40) | LMNAALDH1A1HTT | |
| SCHEMBL4022452 | 0.83 | ALDH1A1 (0.40) | LMNAALDH1A1HTT | |
| SCHEMBL4019392 | 0.80 | MAPK1 (0.42) | LMNAALDH1A1MMP1MMP2MMP9 | |
| SCHEMBL4028626 | 0.80 | MAPK1 (0.42) | LMNAALDH1A1MMP1MMP2MMP9 | |
| SCHEMBL6198772 | 0.76 | MAPK1 (0.39) | ALDH1A1MMP1MMP2MMP9MMP13 | |
| SCHEMBL13720582 | 0.73 | TSHR (0.41) | LMNA | |
| SCHEMBL4681344 | 0.73 | TSHR (0.41) | LMNA | |
| SCHEMBL4021847 | 0.70 | MAOB (0.50) | LMNA | |
| SCHEMBL13720305 | 0.70 | MAOB (0.50) | LMNA | |
| SCHEMBL4020752 | 0.70 | MAOB (0.50) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569934-B1 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1569934-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004055010-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |