Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 8/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4934721 | 0.99 | DRD2 (0.51) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4687018 | 0.87 | DRD2 (0.62) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4683536 | 0.87 | DRD2 (0.53) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4688656 | 0.87 | DRD2 (0.55) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4684374 | 0.87 | DRD2 (0.55) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4687728 | 0.86 | HTR2A (0.55) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4684298 | 0.86 | DRD2 (0.59) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4689635 | 0.86 | DRD2 (0.53) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4685505 | 0.86 | DRD2 (0.53) | DRD2DRD3ADRA1AHTR7SIGMAR1 | |
| SCHEMBL4688104 | 0.85 | DRD2 (0.60) | DRD2DRD3ADRA1AHTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828125-B1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET SOC CIV (FR) | 2008-04-09 | — | — | EP | claimed |
| EP-1828125-B1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET SOC CIV (FR) | 2008-04-09 | — | — | EP | disclosed |
| EP-1828125-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006058993-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANDS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2006-06-08 | — | — | WO | disclosed |