SCHEMBL4685197

SCHEMBL4685197

C=C(C)n1nc(-c2ccc(OC(F)(F)F)cc2)cc1CC(NC)c1ccc(OC(C)(C)C(=O)O)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 13/20 0.42
PPARA Q07869 13/20 0.42
PPARG P37231 6/20 0.42
GCGR P47871 7/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4681945 0.91 PPARA (0.37) PPARDPPARAPPARGGCGR
SCHEMBL6191963 0.91 PPARD (0.39) PPARDPPARAPPARGGCGR
SCHEMBL4681924 0.89 PPARD (0.45) PPARDPPARAPPARGGCGR
SCHEMBL4681905 0.84 GCGR (0.42) PPARDPPARAPPARGGCGR
SCHEMBL4786216 0.80 PPARA (0.45) PPARDPPARAPPARG
SCHEMBL4677933 0.80 PPARA (0.39) PPARDPPARAPPARGGCGR
SCHEMBL4679365 0.79 PPARD (0.43) PPARDPPARAPPARGGCGR
SCHEMBL4679263 0.78 PPARD (0.43) PPARDPPARAPPARG
SCHEMBL4679233 0.77 PPARD (0.48) PPARDPPARAPPARG
SCHEMBL4683164 0.77 PPARD (0.43) PPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1513796-B1 PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORP (US) 2008-02-13 EP claimed
US-7241793-B2 Phenyloxyalkanonic acid derivatives as hPPAR activators SMITHKLINE BEECHAM CORPORATION (US) 2007-07-10 US claimed
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators SMITHKLINE BEECHAM CORPORATION 2005-10-06 US claimed
EP-1513796-B1 PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORP (US) 2008-02-13 EP disclosed
US-7241793-B2 Phenyloxyalkanonic acid derivatives as hPPAR activators SMITHKLINE BEECHAM CORPORATION (US) 2007-07-10 US disclosed
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators SMITHKLINE BEECHAM CORPORATION 2005-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators CEL, HPN, LIPA PPARD 223/4885PPARA 54/4885PPARG 70/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.