Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688655 | 0.91 | MEN1 (0.44) | ALDH1A1RAD51NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL5790936 | 0.84 | NR1H2 (0.67) | ALDH1A1NR1H2NR1H3SMN1; SMN2MAPT | |
| SCHEMBL5746128 | 0.81 | NR1H2 (0.51) | ALDH1A1NR1H2NR1H3SMN1; SMN2MAPT | |
| SCHEMBL4685924 | 0.80 | NPC1 (0.46) | ALDH1A1RAD51NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL4685918 | 0.79 | NR1H2 (0.60) | ALDH1A1RAD51NR1H2NR1H3MAPT | |
| SCHEMBL4692961 | 0.79 | RAD51 (0.41) | ALDH1A1RAD51NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL5748763 | 0.77 | NR1H2 (0.65) | ALDH1A1NR1H2NR1H3SMN1; SMN2MAPT | |
| SCHEMBL4687894 | 0.73 | NR1H2 (0.76) | ALDH1A1NR1H2NR1H3SMN1; SMN2MAPT | |
| SCHEMBL3642366 | 0.73 | RAB9A (0.65) | ALDH1A1SMN1; SMN2MAPTRAB9ATDP1 | |
| SCHEMBL15451446 | 0.73 | NR1H2 (0.56) | RAD51NR1H2NR1H3PDE4BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432288-B2 | Pyrrole-2,5-dione derivatives as Liver X receptor modulators | ASTRAZENECA AB (SE) | 2008-10-07 | — | — | US | disclosed |
| EP-1646626-B1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| EP-1646625-B1 | PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| US-20060235015-A1 | Pyrrole-2,5-dione derivatives as liver x receptor modulators | ASTRAZENECA AB (SE) | 2006-10-19 | — | — | US | disclosed |
| US-20060189663-A1 | Pyrrole-2,5-dithione derivatives as liver x receptor modulators | ASTRAZENECA AB (SE) | 2006-08-24 | — | — | US | disclosed |
| EP-1646625-A1 | PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | disclosed |
| WO-2005005416-A1 | PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189663-A1 | Pyrrole-2,5-dithione derivatives as liver x receptor modulators | NR1H2, NR1H3, NR1H4 | ALDH1A1 3164/4885RAD51 4646/4885NR1H2 1/4885 |
| US-20060235015-A1 | Pyrrole-2,5-dione derivatives as liver x receptor modulators | NR1H2, NR1H3, SREBF2 | ALDH1A1 3161/4885RAD51 4519/4885NR1H2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.