Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.73 |
| ▸ | PRKCG | P05129 | 12/20 | 0.73 |
| ▸ | PRKCB | P05771 | 12/20 | 0.73 |
| ▸ | PRKCA | P17252 | 12/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.73 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.72 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.72 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690090 | 0.86 | GSK3B (0.71) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL3774788 | 0.86 | GSK3B (0.80) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL4689125 | 0.86 | GSK3B (0.73) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL5757178 | 0.85 | GSK3B (0.79) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL3775079 | 0.85 | GSK3B (1.00) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL5755363 | 0.84 | GSK3B (0.77) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL3774124 | 0.84 | PRKCA (1.00) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL5755163 | 0.83 | GSK3B (1.00) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL5759641 | 0.83 | PRKCA (0.95) | GSK3BPRKCGPRKCBPRKCAKCNH2 | |
| SCHEMBL3774039 | 0.82 | GSK3B (1.00) | GSK3BPRKCGPRKCBPRKCAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439363-B2 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors | JANSSEN PARMACEUTICA N.V. (BE) | 2008-10-21 | — | — | US | disclosed |
| US-7439363-B2 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors | JANSSEN PARMACEUTICA N.V. (BE) | 2008-10-21 | — | — | US | disclosed |
| US-7439363-B2 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors | JANSSEN PARMACEUTICA N.V. (BE) | 2008-10-21 | — | — | US | disclosed |
| EP-1654255-B1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1654255-B1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1654255-A1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-10 | — | — | EP | disclosed |
| US-20050004201-A1 | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors | JANSSEN PHARMACEUTICA (BE) | 2005-01-06 | — | — | US | disclosed |
| WO-2005000836-A1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | WO | disclosed |
| WO-2005000836-A1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004201-A1 | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors | MAP2K2, MAP2K6, MAP3K2 | GSK3B 507/4885PRKCG 149/4885PRKCB 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.