Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419922 | 0.88 | GRM5 (0.42) | GRM5CYP2C19PGRPOLB | |
| SCHEMBL4432498 | 0.78 | PIK3CD (0.40) | GRM5CYP2C19 | |
| SCHEMBL4426224 | 0.78 | PGR (0.47) | GRM5CYP2C19PGRPOLB | |
| SCHEMBL4686013 | 0.77 | — | — | |
| SCHEMBL4423520 | 0.77 | WRN (0.40) | CYP2C19 | |
| SCHEMBL4426157 | 0.76 | CYP2C19 (0.44) | GRM5CYP2C19 | |
| SCHEMBL4423877 | 0.76 | WRN (0.45) | GRM5CYP2C19 | |
| SCHEMBL4421759 | 0.76 | PIK3CD (0.46) | GRM5CYP2C19 | |
| SCHEMBL13707060 | 0.75 | CYP2C19 (0.47) | GRM5CYP2C19PGRPOLB | |
| SCHEMBL4425803 | 0.74 | GAA (0.41) | GRM5CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |