Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422442 | 0.84 | ALDH1A1 (0.40) | PRKDCALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4686013 | 0.82 | — | — | |
| SCHEMBL4433379 | 0.81 | MAPT (0.39) | PRKDCALDH1A1SMN1; SMN2TSHRNPC1 | |
| SCHEMBL4423870 | 0.79 | ALDH1A1 (0.40) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4429744 | 0.77 | MAPT (0.38) | PRKDCALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL4426157 | 0.77 | CYP2C19 (0.44) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL4421767 | 0.77 | CYP2C19 (0.45) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4418704 | 0.75 | NPC1 (0.39) | PRKDCALDH1A1SMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL4423877 | 0.75 | WRN (0.45) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL4428642 | 0.75 | GRM5 (0.47) | PRKDCALDH1A1SMN1; SMN2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |