Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830782 | 0.91 | PRMT3 (0.39) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL1831585 | 0.87 | — | — | |
| SCHEMBL1831024 | 0.87 | EPHX1 (0.39) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL4693176 | 0.84 | PRMT3 (0.36) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL17919508 | 0.80 | KDM4C (0.42) | PRMT1 | |
| SCHEMBL17919498 | 0.80 | KDM4A (0.33) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL17919658 | 0.80 | KDM4A (0.35) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL17919568 | 0.78 | TSHR (0.45) | — | |
| SCHEMBL15605976 | 0.76 | PRMT3 (0.31) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL8395168 | 0.76 | CYP2C19 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |
| US-5973094-A | Functional polymers | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0794199-A2 | Novel functional polymers | WAKO PURE CHEMICAL INDUSTRIES, LTD (JP) | 1997-09-10 | — | — | EP | disclosed |