Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175014 | 0.80 | CCNK (0.41) | PPARAGPR35PIM1CYP2A6CYP3A4 | |
| SCHEMBL3195222 | 0.74 | CYP2A6 (0.44) | GPR35CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL3262846 | 0.68 | GRM5 (0.37) | LMNA | |
| SCHEMBL3198741 | 0.66 | NPC1 (0.39) | GPR35CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL3181981 | 0.66 | GPR35 (0.41) | GPR35CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL3174769 | 0.65 | GCK (0.47) | GPR35CYP2A6CYP3A4CYP2E1CYP2C9 | |
| SCHEMBL3186655 | 0.65 | GRM5 (0.47) | GPR35CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL28073818 | 0.63 | CYP2A6 (0.46) | GPR35CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL9384083 | 0.62 | KMT2A (0.62) | PIM1CYP2A6CYP3A4CYP2C19CYP2E1 | |
| SCHEMBL3379615 | 0.61 | CKS1B (0.43) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948667-A2 | THIAZOLO[4,5-C]PYRIDINE DERIVATIVES AS MGLU5 RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-30 | — | — | EP | claimed |
| WO-2007054436-A2 | THIAZOLO [4 , 5-C] PYRIDINE DERIVATIVES AS MGLU5 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-18 | — | — | WO | claimed |