Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687023 | 1.00 | HSD17B10 (0.64) | HSD17B10KMT2AMEN1RXFP1MAOB | |
| SCHEMBL4687025 | 1.00 | HSD17B10 (0.64) | HSD17B10KMT2AMEN1RXFP1MAOB | |
| SCHEMBL5477342 | 0.88 | HSD17B10 (0.66) | HSD17B10KMT2AMEN1RXFP1MAOB | |
| SCHEMBL5477339 | 0.88 | HSD17B10 (0.66) | HSD17B10KMT2AMEN1RXFP1MAOB | |
| SCHEMBL14520811 | 0.88 | HSD17B10 (0.66) | HSD17B10KMT2AMEN1RXFP1MAOB | |
| SCHEMBL14482921 | 0.82 | MAPT (0.63) | HSD17B10KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL1975201 | 0.82 | MAPT (0.63) | HSD17B10KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL1975200 | 0.82 | MAPT (0.63) | HSD17B10KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL29217657 | 0.82 | MEN1 (0.56) | HSD17B10KMT2AMEN1MMP1MMP2 | |
| SCHEMBL29217646 | 0.82 | MAPT (0.59) | HSD17B10KMT2AMEN1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537081-B1 | DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2008-10-15 | — | — | EP | disclosed |
| EP-1458682-B1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2006-08-30 | — | — | EP | disclosed |
| EP-1537081-A1 | DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | Bayer HealthCare AG (DE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1458682-A1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | Bayer HealthCare AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2004020412-A1 | DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-03-11 | — | — | WO | disclosed |
| WO-2003053930-A1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |